Researchers are exploring the development of 3D in vitro models of skeletal muscle to study muscle pathology. Various studies are investigating the use of different cells and scaffolds to create these models, with some focusing on specific aspects such as myogenesis, calcium handling, and muscle regeneration. The field appears to be advancing with the help of bioengineering strategies and the use of human cells, including induced pluripotent stem cells, to create more accurate models of skeletal muscle function and disease.