Presentations at the ESMO 2025 conference have highlighted notable developments in oncology. The event featured discussions on various topics, including genitourinary oncology and breast cancer, with some presentations potentially having practice-changing implications. Specific details on the presentations, such as the use of ozekibart in treating Ewing sarcoma, have been reported, but the overall significance and key takeaways from the conference are still being discussed by oncology experts.