Research suggests that the microenvironment of colorectal cancer plays a role in determining the prognosis of the disease. Studies have identified various biomarkers and genes associated with the tumor microenvironment that may be used to predict prognosis and response to immunotherapy or chemotherapy. The specific markers and their implications are being explored in ongoing research, with some studies focusing on the immunological landscape and others on the molecular and histological features of aggressive colorectal cancers.