Researchers are exploring the tumor microenvironment to develop new therapeutic approaches, with a focus on various forms of cell death, including ferroptosis and cuproptosis. The interactions between cancer cells and immune cells in this environment are being studied to understand how cancer evades the immune system and to identify potential targets for therapy. Different aspects of the tumor microenvironment, such as metabolic crosstalk, RNA editing, and senescent immune cells, are being investigated for their roles in cancer immune evasion and potential therapeutic implications.