Research suggests a link between changes in the oral microbiome and relapsing-remitting multiple sclerosis. Some studies indicate that oral dysbiosis and the presence of certain periodontal pathogens may be associated with the disease, while others explore the relationship between the oral microbiome and multiple sclerosis disease severity. The exact nature of this relationship is still being investigated, with various studies examining the metabolite signature of an altered oral microbiota and its potential impact on the disease.