A at single-molecular resolution via direct RNA sequencing and realistic training data

Nature·Apr 18

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Researchers have made advancements in direct RNA sequencing, allowing for the examination of RNA structures at single-molecular resolution. This technology has enabled the detection of RNA modifications and the mapping of their dynamics and interactions. The development of new methods and tools, such as nanopore direct RNA-sequencing and deep learning algorithms, is reportedly facilitating a deeper understanding of RNA biology and its potential applications in medicine.

Full coverage

Direct RNA sequencing and signal alignment reveal RNA structure ensembles in a eukaryotic cell

Nature·Apr 24

Reading between the bases: technological advances in RNA modification detection

Frontiers·May 25

New RNA sequencing method reveals molecular structures at single-molecule resolution

Drug Target Review·May 15

A sites in the human transcriptome at single-molecule resolution

Nature·Dec 15

Comprehensive mapping of RNA modification dynamics and crosstalk via deep learning and nanopore direct RNA-sequencing

Nature·Jan 14

Charting a Future for Sequencing RNA and Its Modifications: A New Era for Biology and Medicine

National Academies of Sciences, Engineering, and Medicine·Dec 7

AvaII senses m6A and inosine sites and enables targeted nanopore direct RNA-sequencing

Frontiers·Jul 14

DirectRM: integrated detection of landscape and crosstalk between multiple RNA modifications using direct RNA sequencing

Nature·Oct 27

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