Organ transplantation has a notable history, with various milestones achieved in the field. Reports indicate that several individuals have made history through their involvement in organ transplantation, including a man who underwent a risky experiment, a woman who received multiple transplanted organs at once, and a 100-year-old man who became the oldest organ donor in the US. The topic of organ transplantation is also being discussed in the context of regional shortages and regulatory frameworks in countries such as South Africa and India.