A phylogenetic approach to study the evolution of somatic mutational processes in cancer
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Researchers are using phylogenetic approaches to study the evolution of somatic mutational processes in cancer. This involves analyzing somatic mutations and other factors, such as dna methylation and variant allele frequency, to understand the evolutionary dynamics of cancer. Studies are exploring various aspects of cancer evolution, including clonal dynamics, mutation rates, and developmental lineages, using techniques like tumor bulk sequencing and probabilistic integration of clonal population information.
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