Researchers are exploring various approaches to controlling hypertension, including a synthetic angiotensin II/ACE2-based hormone shunt. Studies are also investigating the potential anti-hypertensive effects of certain compounds, such as curcumin and catechin, which may work by down-regulating or inhibiting components of the renin-angiotensin system. The role of different proteins and pathways, including the protective arm of the renin-angiotensin system, is also being examined in the context of cardio-renal diseases.