APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition

Nature·Nov 11

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Research in mice has shown that switching from the APOE4 allele to the APOE2 allele may improve Alzheimer's disease-related symptoms, including metabolic signatures, neuropathology, and cognition. This allelic switching appears to reduce Alzheimer's pathology and improve memory in adult mice. The role of APOE alleles in brain energy metabolism and their implications for Alzheimer's disease is also being explored.

Full coverage

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

News-Medical·Nov 12

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Medical Xpress·Dec 1

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EurekAlert!·May 13

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Nature·Aug 25

View original report at Nature ↗

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