Antagonistic pleiotropy in disease tolerance: Foxo1-Trim63 axis as double-edged sword in age-dependent sepsis
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researchers are studying the role of the foxo1-trim63 axis in disease tolerance, specifically in relation to age-dependent sepsis. this axis is described as a double-edged sword, suggesting it may have both positive and negative effects. the study appears to be focused on understanding the complex relationship between this axis and sepsis in different age groups.