Research has been conducted on the use of adjunctive antipsychotic therapies in treating major depressive disorder, with studies comparing the efficacy and tolerability of various treatments. Some reports suggest that lumateperone may be a favorable option among these therapies, with one analysis indicating it shows the greatest efficacy improvement. The use and approval of adjunctive therapies for major depressive disorder appears to be an ongoing area of study and development, with some indications of underuse in treatment.