Research is being conducted on the relationship between the gut microbiota and various diseases. Studies have examined the gut microbiota and metabolite profiles in connection with several health conditions, including Kashin-Beck disease, an endemic osteoarthritis in China. The findings of these studies suggest that alterations in the gut microbiota and metabolite profiles may be associated with different diseases, but the specific details and outcomes of the research on Kashin-Beck disease are not clear from the available information.