Researchers are exploring the use of alternative feedstocks for biomanufacturing during space missions, which could potentially enhance space resiliency and sustainability. Various approaches are being investigated, including microbial and synthetic biology solutions for waste management and biomanufacturing, as well as the use of yeast-driven biomanufacturing. The development of biomanufacturing capabilities in space may also involve the creation of new mediums and methods for managing waste and producing resources.