Research on Alzheimer's disease is focusing on the role of astrocytes, with studies examining changes in their transcriptomic profiles over time. The progression of the disease appears to involve various cellular and molecular mechanisms, including alterations in metabolic pathways and signaling cascades. Findings from different models and studies suggest that astrocytes, as well as other cell types such as microglial and endothelial cells, may play significant roles in the disease's development and progression.