Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism

Nature·Jul 1

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Research is exploring the relationship between mitochondrial dna and autism, including the role of inter-generational transmission and heteroplasmies. Studies are also investigating factors that influence the inheritance of mitochondrial dna, such as maternal age and assisted reproduction. The findings suggest that mitochondrial dna diversity and heteroplasmy may be shaped by various genetic and environmental factors.

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Germline selection shapes human mitochondrial DNA diversity

Science | AAAS·Sep 9

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA

PNAS·Mar 2

Nuclear genetic control of mtDNA copy number and heteroplasmy in humans

Nature·Aug 16

Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

Nature·Feb 9

Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G

Nature·Jun 27

Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro

Nature·May 14

Intergenerational transmission of pathogenic heteroplasmic mitochondrial DNA

Nature·Mar 1

Paternal leakage of mitochondrial DNA and maternal inheritance of heteroplasmy in Drosophila hybrids

Nature·Feb 13

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