A ranking of the best characters in Slay the Spire 2 has been published, with various outlets providing their own tier lists. The rankings appear to include characters such as Ironclad, Silent, Defect, Regent, and Necrobinder, although it is unclear if there is a consensus on the top characters. Some outlets have also published tier lists for relics in Slay the Spire 2, while others have seemingly confused it with a different game, Path of Exile 2.