C9orf72 hexanucleotide repeat expansions impair microglial response in ALS

Nature·Oct 14

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Research suggests that expansions of the c9orf72 hexanucleotide repeat impair the microglial response in amyotrophic lateral sclerosis (ALS). The relationship between c9orf72 and ALS is complex, with studies indicating that it may affect various cellular processes, including translation, autophagy, and immune activation. The exact mechanisms and implications of c9orf72 expansions for ALS and related diseases, such as frontotemporal dementia, are still being investigated.

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