Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration
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Researchers have created transchromosomic mice with human HLA-A/B/C and B2M genes using a mouse artificial chromosome and triple BAC integration. This achievement involves the reconstitution of dna fragments on human artificial chromosomes. The development is related to a panel of human cell lines that have human/mouse artificial chromosomes.