DET1 dynamics underlie cooperative ubiquitination by CRL4DET1-COP1 complexes
✦ NabkaNews BriefAuto-summarized from multiple outlets · verify with the source
Researchers have made a discovery related to the dynamics of DET1 and its role in cooperative ubiquitination. The discovery involves the CRL4DET1-COP1 complex and its function in this process. A cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex has been determined, shedding light on the underlying mechanisms.