Research on the human neocortex has shed light on the diversity of developmental isoforms and their potential role in neuropsychiatric risk mechanisms. Studies have investigated protein changes in the brain and the sequencing of RNA in various brain components, which may help explain how neurodevelopment can go awry. The findings appear to involve the use of advanced techniques such as single-cell and isoform-specific translational profiling, as well as spatial transcriptomics data analysis.