Research on schizophrenia risk is exploring the role of genetic models, including copy number variations, in altering brain transcriptomes. Studies using various models, including human neuronal models and genetic mouse models, have identified dysregulation in certain brain regions and highlighted the complexity of the molecular pathology of schizophrenia. The findings suggest that different genetic variations may have distinct effects on the development and function of the brain, potentially shedding light on the underlying mechanisms of schizophrenia.