research on the circadian clock and its regulation is being explored, with studies examining the role of various mechanisms and systems, including the ubiquitin-proteasome system and molecular crosstalk. the relationship between circadian rhythms and other biological processes, such as extracellular vesicle biogenesis and neurodegenerative disorders, is also being investigated. the use of model systems, including organoids, is being utilized to study circadian clock-related diseases and potential treatments.