Research is being conducted on the dynamics of mitochondrial dna methylation in reproductive cells, including oocytes, embryos, and granulosa cells. Some studies suggest that certain factors, such as oxidative stress and environmental toxicants, can negatively impact embryonic development and ovarian aging, while others propose potential interventions to restore mitochondrial function. The role of mitochondrial epigenetics in reproductive health is being explored from various perspectives, including its impact on fertility and longevity.