Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting

Nature·Jan 23

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Research suggests that Dppa3 expression plays a crucial role in the generation of fully reprogrammed iPS cells. The maintenance of Dlk1-Dio3 imprinting is also linked to Dppa3 expression. The process of reprogramming somatic cells to pluripotent cells involves complex mechanisms, including chromatin reorganization and DNA demethylation pathways.

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