E2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft
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research is being conducted on the e2 superfamily of ubiquitin-conjugating enzymes. the enzymes are reported to be either constitutively active or activated through a specific process. the process of activation is possibly related to phosphorylation in the catalytic cleft, though the exact nature of this relationship is not clear.