Researchers are exploring the use of biomarkers in blood and urine to detect Parkinson's disease before clinical diagnosis. Some studies suggest that certain biomarkers, including those related to immune function and protein profiles, may aid in diagnosing the disease. The specific biomarkers and methods being investigated vary, with some reports mentioning the potential of multiplex blood and urine biomarkers and others discussing the use of proteomic profiling and large-scale proteomics.