Research has been conducted on the efficacy and safety of vericiguat in treating heart failure, with studies examining its effects in various patient populations. The results of these studies, including randomized controlled trials and real-world cohort analyses, have been compiled in systematic reviews and meta-analyses. Findings suggest that vericiguat may be associated with positive outcomes and limited side effects in heart failure patients, although the specifics of these outcomes are not uniformly reported across the studies.