Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

Nature·Nov 1

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Research suggests that fatty acid synthase plays a crucial role in the growth and proliferation of certain cells, including cancer cells and pathogens. The enzyme's involvement in fatty acid synthesis has been implicated in various diseases, including cancer and atherosclerosis. Studies have explored the mechanisms and potential therapeutic targets related to fatty acid synthase and its role in cell growth and disease progression.

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c-Myc/GRPEL1 maintains fatty acid synthesis via FASN to support PDAC cell proliferation

Nature·Feb 5

A review on the role of fatty acids in colorectal cancer progression

Frontiers·Feb 7

Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

Science | AAAS·Mar 14

The Stearoyl-Coenzyme A Desaturase 1 Is Essential for Virulence and Membrane Stress in Candida parapsilosis through Unsaturated Fatty Acid Production

ASM Journals·Sep 17

Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence

PNAS·Apr 14

Structural dynamics of human fatty acid synthase in the condensing cycle

Nature·Feb 20

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

PNAS·Aug 29

Targeting fatty acid synthase reduces aortic atherosclerosis and inflammation

Nature·Feb 19

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