FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53
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Research suggests that FLT4 activation may contribute to the survival of acute lymphoid leukemia cells by stabilizing MDM2/MDMX and inactivating p53. However, the relationship between this process and other molecular mechanisms, such as AXL signaling and leukotriene C4, is also being explored. The exact role of these various factors in leukemia survival is still being investigated.