Research has implicated distinct transcriptional networks in dementia, with studies examining the functional impact of regulatory variants on the disease. The investigations involve various approaches, including CRISPRi screening and massively parallel variant-to-function mapping, to understand the role of genetic variants in dementia and other conditions. The findings appear to have implications for understanding the immune mechanisms and genetic insights of neurodegenerative diseases, including Alzheimer's and Parkinson's disease.