Research suggests that histone lactylation plays a role in promoting cancer progression in various types of cancer. Studies have found that histone lactylation is involved in modulating different cellular processes, including metabolism, autophagy, and cell cycle arrest, to contribute to tumor growth and resistance to treatment. The specific mechanisms and pathways affected by histone lactylation appear to vary across different cancer types, including oral, prostate, melanoma, hepatocellular, colorectal, and endometrial cancer.