Researchers are exploring strategies to transform "cold" tumors into "hot" tumors to enhance immune activation and improve immunotherapy outcomes. Various approaches are being investigated, including modulating the tumor microenvironment and utilizing hypoxia, hyperthermia, and targeted therapies. The goal of these efforts is to increase the effectiveness of immunotherapies, such as immune checkpoint inhibitors, in treating different types of cancer, including breast, colorectal, and pancreatic cancer.