Research on chimeric antigen receptor T cells, also known as CAR-T cells, is ongoing, with a focus on improving their safety and effectiveness in cancer immunotherapy. Some studies are exploring new strategies, such as switchable adapters and combination therapies, to enhance their potency and reduce risks. The field is actively investigating various approaches, including the use of CAR-NK cells and microenvironment remodeling, to overcome challenges in treating different types of cancer.