Research on Parkinson's disease models has shown promise for rescuing dopaminergic neurons through various methods, including gene therapy and other therapeutic approaches. Different studies have explored various mechanisms, such as targeting alpha-synuclein and stimulating dopamine neurons, with some showing potential for alleviating symptoms. The effectiveness of these methods is being investigated in multiple in vitro and in vivo models, with some studies focusing on specific aspects of the disease, such as early-onset Parkinson's or synaptic plasticity deficits.