Research on in vivo acoustic and photoacoustic focusing of circulating cells is being explored for various medical applications. The technology, which may involve a device referred to as a Cytophone, appears to have potential for disease diagnosis and treatment, including the detection of circulating tumor cells in patients with melanoma. Its possible uses also extend to other areas, such as neuroimaging and the detection of diseases like malaria, with some studies focusing on its efficiency and applications in both preclinical and clinical settings.