IllustrativeLEM4 interacts with β-catenin and promotes β-catenin-dependent transcription activity to confers ribociclib resistance in breast cancer cells
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Research suggests that LEM4 interacts with β-catenin, promoting β-catenin-dependent transcription activity. This interaction is reported to contribute to resistance to ribociclib in breast cancer cells. The study appears to have identified a mechanism by which breast cancer cells develop resistance to ribociclib.