Research suggests that lysine methylation plays a role in activating NFAT5, which in turn affects the effectiveness of temozolomide in treating glioblastoma. The relationship between lysine methylation and NFAT5 activation may be a factor in determining the efficacy of temozolomide. Lysine methylation's impact on NFAT5 and temozolomide efficacy in glioblastoma has been identified in a recent study.