Molecular driving force of a small molecule-induced protein disorder-order transition

Nature·Jan 14

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1

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

Science | AAAS·Feb 27

2

Folded domains impose structural heterogeneity and attenuated dynamics in biomolecular condensates

Nature·Apr 16

3

Decoupling phase separation and fibrillization preserves activity of biomolecular condensates

Nature·Feb 16

4

Enhancing response of a protein conformational switch by using two disordered ligand binding domains

Frontiers·Mar 1

5

Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states

Nature·Oct 27

6

Small-molecule-induced liquid-liquid phase separation suppresses the carcinogenesis of β-catenin

Nature·Jul 1

7

Thermodynamic forces from protein and water govern condensate formation of an intrinsically disordered protein domain

Nature·Sep 21

8

New insights into protein–protein interaction modulators in drug discovery and therapeutic advance

Nature·Dec 6