Researchers are studying metabolic reprogramming in lung cancer, exploring its hallmarks, mechanisms, and potential targeted strategies to overcome immune resistance. The role of various factors, including circRNAs, lactylation, and non-coding RNAs, in metabolic reprogramming and cancer progression is being investigated. Studies are also examining the relationship between metabolic reprogramming and other cellular processes, such as epigenetic modification and genome integrity, to inform the development of precision immunotherapies.