Research suggests that SARS-CoV-2 accessory proteins, including ORF3a, ORF9b, ORF9c, and ORF10, may induce alterations in metabolism and mitochondria. Studies have found associations between SARS-CoV-2 infection and changes in mitochondrial function, as well as disruptions to various cellular processes. The exact mechanisms and implications of these changes are being explored, with potential connections to immune evasion, viral replication, and disease severity.