Researchers have developed a method called MitoPerturb-Seq to study the effects of mitochondrial DNA depletion and heteroplasmy on individual cells. This technology has been used in conjunction with other methods, such as single-cell multi-omic analysis and mtDNA enrichment techniques, to investigate mitochondrial mutational mosaicism and dynamics. The studies have potential applications in understanding and diagnosing mitochondrial disorders, although the specific findings and implications are not fully detailed.