Researchers are exploring various strategies to improve therapy for glioblastoma, including nanoparticle-based delivery of proteasome inhibitors to overcome the blood-brain barrier and therapeutic resistance. Other approaches being investigated include targeting regulated cell death pathways, harnessing ferroptosis, and utilizing proteolysis targeting chimera nanotechnology. The development of new delivery systems and therapeutic strategies, such as oncolytic therapy and nano-formulations, is also being studied for the treatment of glioblastoma and other cancers.