Researchers are exploring the use of nanotechnology to combat SARS-CoV-2 variants, including the development of vaccines, drugs, and antibodies. Various studies have investigated the effectiveness of nanoparticles and nanomaterials in inhibiting SARS-CoV-2 infection and eliciting an immune response. The usefulness of these nanotechnology-based strategies against emerging variants of concern is being examined, with some studies reporting promising results.