SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation

Nature·Sep 2

✦ NabkaNews BriefAuto-summarized from multiple outlets · verify with the source

Research suggests that SIRT2 activates G6PD, leading to increased NADPH production and promotion of leukemia cell proliferation. The role of G6PD and related pathways, such as the pentose phosphate pathway, appears to be significant in various cellular processes, including cancer metabolism and cell proliferation. The relationship between G6PD activity and cellular outcomes, including apoptosis and chemosensitivity, is also being explored.

Full coverage

Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases

Frontiers·Feb 5

The role of acetylation and deacetylation in cancer metabolism - Wang - 2025 - Clinical and Translational Medicine

Wiley Online Library·Jan 7

The p52-ZER6/G6PD axis alters aerobic glycolysis and promotes tumor progression by activating the pentose phosphate pathway

Nature·Mar 28

The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

Frontiers·Oct 28

NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH

Nature·Aug 20

Acetylation-dependent coupling between G6PD activity and apoptotic signaling

Nature·Oct 5

Variation in pentose phosphate pathway-associated metabolism dictates cytotoxicity outcomes determined by tetrazolium reduction assays

Nature·May 22

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer

Nature·Jul 10

View original report at Nature ↗

Fetching the latest headlines…