Research suggests that soluble programmed death-ligand 1 is a more effective predictor of metastasis and prognosis in soft tissue sarcomas than PD-L1 on tumor cells. The role of soluble programmed death-ligand 1 as a prognostic biomarker is also being explored in other types of cancer, including non-small cell lung cancer and gastric cancer. The PD-1/PD-L1 axis is a topic of ongoing study in the field of cancer research, with various studies investigating its significance and potential applications.