Researchers are exploring the use of semiconducting polymer nano-PROTACs for cancer therapy, potentially enabling activatable photo-immunometabolic treatments. Various studies are investigating the application of light-activated nanomaterials and nanoparticles in combination cancer immunotherapy, targeting different types of cancer, including colorectal and breast cancer. The approaches being investigated aim to enhance cancer treatment efficacy through precise delivery and degradation mechanisms, as well as immunotherapy and metabolic reprogramming.