Research has shed light on the genetic programs driving lipid droplet heterogeneity in hepatic steatosis through a single cell multiomic landscape. However, the specific findings and focus of the research appear to be unclear, with various studies exploring different aspects of metabolic dysfunction and disease. The use of single-cell multi-omics has been applied to various areas of study, including liver disease, cardiac metabolism, and cancer, but the direct connection to hepatic steatosis is uncertain.