Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease

Science | AAAS·Apr 8

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Researchers have used single-cell eQTL mapping to identify cell type-specific genetic control of various diseases. The technique has been applied to several conditions, including autoimmune diseases, inflammatory bowel disease, and COVID-19 infection, revealing cell type-specific genetic regulation. The specific diseases and mechanisms being studied appear to vary, with some outlets reporting on immune-related conditions and others on diseases such as cholelithiasis and neuropsychiatric disorders.

Full coverage

Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping

Nature·Apr 22

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

Nature·Jun 3

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infection

medRxiv·Jun 30

Single-cell splicing QTL analysis in pancreatic islets

Frontiers·Sep 9

Single-cell eQTL mapping of human endogenous retroviruses reveals cell type-specific genetic regulation in autoimmune diseases

Nature·Aug 14

Immune-cell-specific genetic drivers of cholelithiasis revealed by single-cell transcriptome-wide Mendelian randomization and colocalization

Nature·Apr 17

Airqtl dissects cell state-specific causal gene regulatory networks with efficient single-cell eQTL mapping

Nature·Dec 10

T cell activation reveals immune-mediated mechanisms and drug targets for neuropsychiatric disorders

Nature·Mar 29

View original report at Science | AAAS ↗

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