PARG inhibition suppresses breast cancer progression and potentiates immunoresponse through MTDH degradation mediated by E3 ligase ITCH-dependent ubiquitination
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Research suggests that inhibiting PARG may slow the progression of breast cancer and enhance the body's immune response. This process appears to involve the degradation of MTDH, which is mediated by the E3 ligase ITCH-dependent ubiquitination. The specifics of this relationship are being studied in the context of poly (ADP-ribose) glycohydrolase's role in cancer.